Recombinant Anti-CD64 x Anti-malaria antigen Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD64 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-malaria antigen scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget NK cells to genus plasmodium. It is designed for the research of Malaria therapy.