Home > Products > CD89 & EGFR > Recombinant Human Anti-CD89 x Human Anti-EGFR Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CD89 x Human Anti-EGFR Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H305)

Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD89 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-EGFR to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget macrophages to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Non-small cell lung cancer (NSCLC); Solid tumors therapy.

Specifications
Targets
CD89 & EGFR
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD89
Host Animal 1
Human
Target 2
EGFR
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Non-small cell lung cancer (NSCLC); Solid tumors
Targets
Target 1
CD89
Gene ID
UniProt ID
Alternative Names
FcαRI; FCAR; Fc fragment of IgA, receptor for; CD89; FcalphaRI; immunoglobulin alpha Fc receptor; Fc alpha receptor
Target 2
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
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