Home > Products > CD89 & HIV-1 gp41 > Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H306)

Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD89 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-HIV-1 gp41 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget macrophages to tumor cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Specifications

Targets
CD89 & HIV-1 gp41
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD89
Host Animal 1
Human
Target 2
HIV-1 gp41
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS

Targets

Target 1
CD89
Gene ID
UniProt ID
Alternative Names
FcαRI; FCAR; Fc fragment of IgA, receptor for; CD89; FcalphaRI; immunoglobulin alpha Fc receptor; Fc alpha receptor
Target 2
HIV-1 gp41
Gene ID
UniProt ID
Alternative Names
ENV; gp160; Envelope glycoprotein 120; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain; human immunodeficiency virus type 1; human immunodeficiency virus type 1 gp120; human immunodeficiency virus type 1 glycoprotein 120; gp41; GP41; glycoprotein 41

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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