Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-CD89 antibody are fused with the VL and VH domains of an anti-S. pneumoniae antibody respectively. It can form natural in vivo heterodimerization. This BsAb can retarget NK cells to genus plasmodium. It is designed for the research of S. pneumoniae infection therapy.