Home > Products > CEA & 4-1BB > Recombinant Human Anti-CEA x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CEA x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc)  (CAT#: KN-0825-N43)

Recombinant Human Anti-CEA x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CEA antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-4-1BB to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can activate 4-1BB signaling, leading to T cell activation against CEA-overexpressing tumors. It is designed for the research of Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer therapy.
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Specifications

Targets
CEA & 4-1BB
Type
Fab-scFv/sdAb-Fc
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer
Host Animal 1
Human
Host Animal 2
Human

Targets

Target 1
CEA
Gene ID
1048
UniProt ID
A0A024R0K5
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
4-1BB
Gene ID
3604
UniProt ID
Q07011
Alternative Names
CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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