Home > Products > CEA & DR5 > Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody-Fc)

Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody-Fc)  (BSDBF-136)

Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-CEA and anti-DR5 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can induce targeted apoptosis by activation of the death receptor. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Specifications
Targets
CEA & DR5
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CEA
Host Animal 1
Mouse
Target 2
DR5
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
DR5
Gene ID
UniProt ID
Alternative Names
DR5; Death Receptor 5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; TNFRSF10B
Our services and products are only for lab research, not for any diagnostic or therapeutic use.

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