Recombinant Anti-CEA x Anti-nido-carboranes Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-CEA/nido-carboranes tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can be used in pretargeting system of PET, radioimaging or radiotherapy. It can mediate targeting of radioactivity to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer imaging and therapy.
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