Home > Products > CEA & TNFα > Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-scFv-Fc)  (FABVC-142)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CEA antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-TNFα to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget cytokine (TNFα) to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Specifications
Targets
CEA & TNFα
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CEA
Host Animal 1
Mouse
Target 2
TNFα
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
TNFα
Gene ID
UniProt ID
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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