Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Miniantibody) (MNAB-142)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Miniantibody) is a fusion protein of two scFv fragments combined with distinct specificity. One scFv of an anti-CEA antibody variable domain is linked to another scFv of an anti-TNFα antibody variable domain by a flexible hinge region. This BsAb format has the decreased size and better penetration than conventional IgGs in the clinical diagnostics and potentially therapy. This BsAb can retarget cytokine (TNFα) to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CEA & TNFα

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Ovary cancer; Colon cancer; Lung cancer

Targets

Target 1

CEA

Gene ID

1048

UniProt ID

A0A024R0K5

Alternative Names

CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

Target 2

TNFα

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Miniantibody) (CAT#: MNAB-142)

Specifications

Targets

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