Home > Products > CEA & TNFα > Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Minibody)

Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Minibody)  (MiniB-H311)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Minibody) is designed to be expressed as the anti-CEA scFv fused to N-terminus of Knob-CH3 domain and the anti-TNFα scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget cytokine (TNFα) to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Specifications

Targets
CEA & TNFα
Type
Minibody
Species Reactivity
Human
Target 1
CEA
Host Animal 1
Human
Target 2
TNFα
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer

Targets

Target 1
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
TNFα
Gene ID
UniProt ID
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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