Home > Products > CEA & TNFα > Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-Fc)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-Fc)  (BSCFV-H311)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CEA specificity or anti-TNFα specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget cytokine (TNFα) to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Specifications
Targets
CEA & TNFα
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CEA
Host Animal 1
Mouse
Target 2
TNFα
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
TNFα
Gene ID
UniProt ID
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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