Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-IgG) (BSSG-142)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CEA antibody variable domain are respectively connected to the N terminus of the anti-TNFα IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget cytokine (TNFα) to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Datasheet

Specifications

Targets

CEA & TNFα

Type

Appended IgGs

Species Reactivity

Human

Target 1

CEA

Host Animal 1

Mouse

Target 2

TNFα

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Ovary cancer; Colon cancer; Lung cancer

Targets

Target 1

CEA

Gene ID

1048

UniProt ID

A0A024R0K5

Alternative Names

CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

Target 2

TNFα

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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