Home > Products > CEA & TNFα > Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Single-chain Diabody)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Single-chain Diabody)  (SCDB-142)

Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can retarget cytokine (TNFα) to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Datasheet
Specifications
Targets
CEA & TNFα
Type
Single-chain Diabody
Species Reactivity
Human
Target 1
CEA
Host Animal 1
Mouse
Target 2
TNFα
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
CEA
Gene ID
1048
UniProt ID
A0A024R0K5
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
TNFα
Gene ID
7124
UniProt ID
P01375
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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