Home > Products > CLDN18.2 & 4-1BB > Recombinant Human Anti-CLDN18.2 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CLDN18.2 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc)  (CAT#: KN-0825-N40)

Recombinant Human Anti-CLDN18.2 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CLDN18.2 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-4-1BB to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can activate 4-1BB signaling, leading to T cell activation against CLDN18.2-overexpressing tumors. It is designed for the research of Solid tumors therapy.
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Specifications

Targets
CLDN18.2 & 4-1BB
Type
Fab-scFv/sdAb-Fc
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Solid tumors
Host Animal 1
Human
Host Animal 2
Human

Targets

Target 1
CLDN18.2
Gene ID
51208
UniProt ID
P56856
Alternative Names
Claudin18.2; CLDN18.2; CLDN18 splice variant 2; Claudin-18 isoform 2; Tight junction protein Claudin-18.2; CLDN18.2 protein; Claudin-18.2; SFTA5; SFTPJ; UNQ778; PRO1572; CLDN18; Claudin-18
Target 2
4-1BB
Gene ID
3604
UniProt ID
Q07011
Alternative Names
CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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