Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (IgG(L)-scFv) (IGLFV-H313)

Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-Csl antibody are fused to the C terminus of an anti-CD3 IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can retarget T cells to tumor cells. It is designed for the research of Breast cancer; Glioma cancaer; Glioblastoma; Multiple myeloma (MM); Leukemia therapy.

Datasheet

Specifications

Targets

Csl & CD3

Type

Appended IgGs

Species Reactivity

Human

Target 1

Csl

Host Animal 1

Human

Target 2

CD3

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Glioma cancaer; Glioblastoma; Multiple myeloma (MM); Leukemia

Targets

Target 1

Csl

Gene ID

3516

UniProt ID

Q06330

Alternative Names

SUH; csl; AOS3; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; RBPSUH; IGKJRB1; recombination signal binding protein for immunoglobulin kappa J region; RBPJ; Lag-1; Suppressor of hairless

Target 2

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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