Name: Recombinan Human Anti-CTLA4 x Human Anti-GITR Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N63
Rating: 5 (1 reviews)

Recombinant Human Anti-CTLA4 x Human Anti-GITR Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CTLA4 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-GITR to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block the CTLA4 signal and active the GITR signal, enhance T cell activation. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CTLA4 & GITR

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CTLA4

Gene ID

1493

UniProt ID

P16410

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Target 2

GITR

Gene ID

8784

UniProt ID

Q9Y5U5

Alternative Names

GITR; Glucocorticoid-Induced TNFR-Related protein; TNFRSF18; Tumor Necrosis Factor Receptor Superfamily Member 18; Activation-Inducible TNFR Family Receptor; AITR; CD357 Antigen; CD357; GITR-D; ENERGEN; Glucocorticoid-induced TNFR-related protein; UNQ319/PRO364

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinan Human Anti-CTLA4 x Human Anti-GITR Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N63)

Specifications

Targets

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