Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Bispecific Antibody (Fab-scFv-Fc) (FABVC-H314)

Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CTLA4 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-GLUT2 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind two factors simultaneously. It is designed for the research of Renal cell cancer (RCC) therapy.

Datasheet INQUIRY

Specifications

Targets

CTLA4 & GLUT2

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Renal cell cancer (RCC)

Targets

Target 1

CTLA4

Gene ID

1493

UniProt ID

P16410

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Target 2

GLUT2

Gene ID

6514

UniProt ID

P11168

Alternative Names

SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; GLUT2; solute carrier family 2, facilitated glucose transporter member 2; glucose transporter type 2, liver

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-H314)

Specifications

Targets

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