Name: Recombinan Human Anti-CTLA4 x Human Anti-IL2RA Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N64
Rating: 5 (1 reviews)

Recombinant Human Anti-CTLA4 x Human Anti-IL2RA Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CTLA4 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-IL2R to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block CTLA4 and IL2RA signals. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CTLA4 & IL2RA

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CTLA4

Gene ID

1493

UniProt ID

P16410

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Target 2

IL2RA

Gene ID

3559

UniProt ID

P01589

Alternative Names

IL-2R; IL2R; Interleukin 2 receptor; p55; CD25; TCGFR; IDDM10; interleukin 2 receptor subunit alpha; IL2RA

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinan Human Anti-CTLA4 x Human Anti-IL2RA Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N64)

Specifications

Targets

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