Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Minibody) (MiniB-H315)

Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CTLA4 scFv fused to N-terminus of Knob-CH3 domain and the anti-PD1 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can bind two factors simultaneously and enhance immune response. It is designed for the research of Tumors therapy.

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Specifications

Targets

CTLA4 & PD1

Type

Minibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Tumors

Targets

Target 1

CTLA4

Gene ID

1493

UniProt ID

P16410

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Target 2

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Minibody) (CAT#: MiniB-H315)

Specifications

Targets

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