Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (VHH-Fc-VHH) (HCAB-042)

Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-CTLA4 and anti-PD1 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can bind two factors simultaneously and enhance immune response. It is designed for the research of Tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CTLA4 & PD1

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Dengue virus infection

Targets

Target 1

CTLA4

Alternative Names

dengue virus; DENV; dengue fever; Flavivirus

Target 2

PD1

Gene ID

2209

UniProt ID

P12314

Alternative Names

FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (VHH-Fc-VHH) (CAT#: HCAB-042)

Specifications

Targets

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