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Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Diabody-CH3)  (BSDBC-H317)

Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-DKK1 and anti-SOST antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind two factors simultaneously and promote osteoblastogenesis. It is designed for the research of Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture therapy.

Specifications

Targets
DKK1 & SOST
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
DKK1
Host Animal 1
Human
Target 2
SOST
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture

Targets

Target 1
DKK1
Gene ID
UniProt ID
Alternative Names
DKKL1; dickkopf-like 1; SGY; CT34; SGY1; SGY-1; dickkopf-like protein 1; soggy; soggy-1; protein soggy-1; cancer/testis antigen 34
Target 2
SOST
Gene ID
UniProt ID
Alternative Names
SOST; sclerostin; CDD; VBCH; SOST1; DAND6

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