Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (F(ab')2-scFv2) (BABFV-148)

Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-DKK1 specificity is fused to the C terminus of the anti-SOST Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind two factors simultaneously and promote osteoblastogenesis. It is designed for the research of Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture therapy.

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Specifications

Targets

DKK1 & SOST

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture

Targets

Target 1

DKK1

Gene ID

27120

UniProt ID

Q9UK85

Alternative Names

DKKL1; dickkopf-like 1; SGY; CT34; SGY1; SGY-1; dickkopf-like protein 1; soggy; soggy-1; protein soggy-1; cancer/testis antigen 34

Target 2

SOST

Gene ID

50964

UniProt ID

Q9BQB4

Alternative Names

SOST; sclerostin; CDD; VBCH; SOST1; DAND6

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-148)

Specifications

Targets

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