Home > Products > DKK1 & SOST > Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H317)

Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-DKK1 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-SOST to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind two factors simultaneously and promote osteoblastogenesis. It is designed for the research of Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture therapy.

Specifications
Targets
DKK1 & SOST
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
DKK1
Host Animal 1
Human
Target 2
SOST
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture
Targets
Target 1
DKK1
Gene ID
UniProt ID
Alternative Names
DKKL1; dickkopf-like 1; SGY; CT34; SGY1; SGY-1; dickkopf-like protein 1; soggy; soggy-1; protein soggy-1; cancer/testis antigen 34
Target 2
SOST
Gene ID
UniProt ID
Alternative Names
SOST; sclerostin; CDD; VBCH; SOST1; DAND6
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