Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-DKK1 IgG with similar domains from an anti-SOST antibody via short peptide linkers, or vice versa. This BsAb can bind two factors simultaneously and promote osteoblastogenesis. It is designed for the research of Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture therapy.
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