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Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fv-IgG)  (BSDG-148)

Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-DKK1 IgG with similar domains from an anti-SOST antibody via short peptide linkers, or vice versa. This BsAb can bind two factors simultaneously and promote osteoblastogenesis. It is designed for the research of Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture therapy.

Specifications

Targets
DKK1 & SOST
Type
Appended IgGs
Species Reactivity
Human
Target 1
DKK1
Host Animal 1
Mouse
Target 2
SOST
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture

Targets

Target 1
DKK1
Gene ID
UniProt ID
Alternative Names
DKKL1; dickkopf-like 1; SGY; CT34; SGY1; SGY-1; dickkopf-like protein 1; soggy; soggy-1; protein soggy-1; cancer/testis antigen 34
Target 2
SOST
Gene ID
UniProt ID
Alternative Names
SOST; sclerostin; CDD; VBCH; SOST1; DAND6

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