Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-CH3) (BSFC-148)

Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-CH3) contains two chains. The anti-DKK1 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-SOST scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind two factors simultaneously and promote osteoblastogenesis. It is designed for the research of Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture therapy.

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Specifications

Targets

DKK1 & SOST

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture

Targets

Target 1

DKK1

Gene ID

27120

UniProt ID

Q9UK85

Alternative Names

DKKL1; dickkopf-like 1; SGY; CT34; SGY1; SGY-1; dickkopf-like protein 1; soggy; soggy-1; protein soggy-1; cancer/testis antigen 34

Target 2

SOST

Gene ID

50964

UniProt ID

Q9BQB4

Alternative Names

SOST; sclerostin; CDD; VBCH; SOST1; DAND6

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-CH3) (CAT#: BSFC-148)

Specifications

Targets

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