Home > Products > DKK1 & SOST > Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv4-Ig)

Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv4-Ig)  (FVTIG-H317)

Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-DKK1 scFv is fused to the CH1 domain of a heavy chain and another anti-SOST scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can bind two factors simultaneously and promote osteoblastogenesis. It is designed for the research of Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture therapy.

Specifications
Targets
DKK1 & SOST
Type
Appended IgGs
Species Reactivity
Human
Target 1
DKK1
Host Animal 1
Human
Target 2
SOST
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Osteoporosis; Osteogenesis imperfecta (OI); Low bone mineral density; Fracture
Targets
Target 1
DKK1
Gene ID
UniProt ID
Alternative Names
DKKL1; dickkopf-like 1; SGY; CT34; SGY1; SGY-1; dickkopf-like protein 1; soggy; soggy-1; protein soggy-1; cancer/testis antigen 34
Target 2
SOST
Gene ID
UniProt ID
Alternative Names
SOST; sclerostin; CDD; VBCH; SOST1; DAND6
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