Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-DLL4 antibody are fused with the VL and VH domains of an anti-VEGF antibody respectively. It can form natural in vivo heterodimerization. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Solid tumors therapy.