Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-DLL4 antibody variable domain are respectively connected to the N terminus of the anti-VEGF IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Solid tumors therapy.