Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv4-Ig) (FVTIG-H318)

Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-DLL4 scFv is fused to the CH1 domain of a heavy chain and another anti-VEGF scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

DLL4 & VEGF

Type

Appended IgGs

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Targets

Target 1

DLL4

Gene ID

54567

UniProt ID

Q9NR61

Alternative Names

DLL4; delta-like 4 (Drosophila); hdelta2; delta-like protein 4; delta like canonical Notch ligand 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4

Target 2

VEGF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv4-Ig) (CAT#: FVTIG-H318)

Specifications

Targets

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