Home > Products > DNMT1 & SHH > Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fab-Fv)

Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fab-Fv)  (FABFV-H319)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-DNMT1 antibody are fused with the VL and VH domains of an anti-SHH antibody respectively. It can form natural in vivo heterodimerization. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Specifications

Targets
DNMT1 & SHH
Type
Fab-Fv
Species Reactivity
Human
Target 1
DNMT1
Host Animal 1
Human
Target 2
SHH
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Hormone refractory breast cancer (HRBC)

Targets

Target 1
DNMT1
Gene ID
UniProt ID
Alternative Names
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1
Target 2
SHH
Gene ID
UniProt ID
Alternative Names
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

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