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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-Fv) (CAT#: BSGV-150)
Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-Fv) is formed by an Immunoglobulin G (IgG) and a fragment variable Fv region, in which the Fc of IgG is engineered by KIH. The Fv region of an anti-DNMT1 antibody variable domain is fused to the C terminal of an IgG of anti-SHH antibody, or vice versa. The format retains desired characteristics of intact antibodies. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.
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