Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Miniantibody) (MNAB-150)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Miniantibody) is a fusion protein of two scFv fragments combined with distinct specificity. One scFv of an anti-DNMT1 antibody variable domain is linked to another scFv of an anti-SHH antibody variable domain by a flexible hinge region. This BsAb format has the decreased size and better penetration than conventional IgGs in the clinical diagnostics and potentially therapy. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Datasheet INQUIRY

Specifications

Targets

DNMT1 & SHH

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hormone refractory breast cancer (HRBC)

Targets

Target 1

DNMT1

Gene ID

1786

UniProt ID

I6L9H2

Alternative Names

AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1

Target 2

SHH

Gene ID

6469

UniProt ID

Q15465

Alternative Names

TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Miniantibody) (CAT#: MNAB-150)

Specifications

Targets

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