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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Minibody) (CAT#: MiniB-150)
Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Minibody) is designed to be expressed as the anti-DNMT1 scFv fused to N-terminus of Knob-CH3 domain and the anti-SHH scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.
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