Home > Products > DNMT1 & SHH > Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH1/CL)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH1/CL)  (BSCC-150)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-DNMT1 antibody variable domain is fused to CH1 and the other scFv from an anti-SHH antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Specifications

Targets
DNMT1 & SHH
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
DNMT1
Host Animal 1
Mouse
Target 2
SHH
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Hormone refractory breast cancer (HRBC)

Targets

Target 1
DNMT1
Gene ID
UniProt ID
Alternative Names
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1
Target 2
SHH
Gene ID
UniProt ID
Alternative Names
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

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