Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-CH3) (BSFC-H319)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH3) contains two chains. The anti-DNMT1 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-SHH scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Datasheet INQUIRY

Specifications

Targets

DNMT1 & SHH

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hormone refractory breast cancer (HRBC)

Targets

Target 1

DNMT1

Gene ID

1786

UniProt ID

I6L9H2

Alternative Names

AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1

Target 2

SHH

Gene ID

6469

UniProt ID

Q15465

Alternative Names

TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-CH3) (CAT#: BSFC-H319)

Specifications

Targets

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