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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc) (CAT#: BSCFV-150)
Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-DNMT1 specificity or anti-SHH specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.
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