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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-150)
Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-DNMT1 scFv is fused to the N-terminus of Fc via a hinge region while another anti-SHH scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.
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