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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv4-Ig) (CAT#: FVTIG-150)
Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-DNMT1 scFv is fused to the CH1 domain of a heavy chain and another anti-SHH scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.
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