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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody)  (SCDB-150)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Specifications

Targets
DNMT1 & SHH
Type
Single-chain Diabody
Species Reactivity
Human
Target 1
DNMT1
Host Animal 1
Mouse
Target 2
SHH
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Hormone refractory breast cancer (HRBC)

Targets

Target 1
DNMT1
Gene ID
UniProt ID
Alternative Names
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1
Target 2
SHH
Gene ID
UniProt ID
Alternative Names
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

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