Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) (SCDB-H317)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

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Specifications

Targets

DNMT1 & SHH

Type

Single-chain Diabody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hormone refractory breast cancer (HRBC)

Targets

Target 1

DNMT1

Gene ID

1786

UniProt ID

I6L9H2

Alternative Names

AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1

Target 2

SHH

Gene ID

6469

UniProt ID

Q15465

Alternative Names

TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) (CAT#: SCDB-H317)

Specifications

Targets

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