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Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv)  (BSFV-150)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) is designed to be expressed as a scFv from an anti-DNMT1 antibody variable domains fused with a scFv from an anti-SHH antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Specifications

Targets
DNMT1 & SHH
Type
Tandem scFv
Species Reactivity
Human
Target 1
DNMT1
Host Animal 1
Mouse
Target 2
SHH
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Hormone refractory breast cancer (HRBC)

Targets

Target 1
DNMT1
Gene ID
UniProt ID
Alternative Names
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1
Target 2
SHH
Gene ID
UniProt ID
Alternative Names
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

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