Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) (BSFV-H316)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) is designed to be expressed as a scFv from an anti-DNMT1 antibody variable domains fused with a scFv from an anti-SHH antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Datasheet INQUIRY

Specifications

Targets

DNMT1 & SHH

Type

Tandem scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hormone refractory breast cancer (HRBC)

Targets

Target 1

DNMT1

Gene ID

1786

UniProt ID

I6L9H2

Alternative Names

AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1

Target 2

SHH

Gene ID

6469

UniProt ID

Q15465

Alternative Names

TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) (CAT#: BSFV-H316)

Specifications

Targets

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