Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Tandem scFv-Fc) (BSFVF-H319)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-DNMT1/SHH tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Datasheet INQUIRY

Specifications

Targets

DNMT1 & SHH

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hormone refractory breast cancer (HRBC)

Targets

Target 1

DNMT1

Gene ID

1786

UniProt ID

I6L9H2

Alternative Names

AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1

Target 2

SHH

Gene ID

6469

UniProt ID

Q15465

Alternative Names

TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Tandem scFv-Fc) (CAT#: BSFVF-H319)

Specifications

Targets

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