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Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Triple Body)  (TRIB-H319)

Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-DNMT1 antibody are both extended with the scFv fragment from an anti-SHH antibody. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.

Specifications

Targets
DNMT1 & SHH
Type
Triple Body
Species Reactivity
Human
Target 1
DNMT1
Host Animal 1
Human
Target 2
SHH
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Hormone refractory breast cancer (HRBC)

Targets

Target 1
DNMT1
Gene ID
UniProt ID
Alternative Names
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA methyltransferase 1; DNMT1
Target 2
SHH
Gene ID
UniProt ID
Alternative Names
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog; SHH; sonic hedgehog (Drosophila) homolog 2; ShhNC

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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