Name: Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (scFv-CH3)
SKU: BSFC-151
Rating: 5 (1 reviews)

Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (scFv-CH3) contains two chains. The anti-doxorubicin scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-EGFR scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can be used in pretargeting system and deliver toxin to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

doxorubicin & EGFR

Type

scFv-CH3

Species Reactivity

Human

Application

FuncS; Pretargeting system for toxin delivery

Related Disease

Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

doxorubicin

Alternative Names

doxorubicin

Target 2

EGFR

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (scFv-CH3) (CAT#: BSFC-151)

Specifications

Targets

Customer Reviews and Q&As