Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH3) contains two chains. The anti-DR5 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-FAP scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can induce targeted apoptosis by activation of the death receptor. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.