Home > Products > DR5 & FAP > Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH3)

Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH3)  (BSFC-H320)

Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH3) contains two chains. The anti-DR5 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-FAP scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can induce targeted apoptosis by activation of the death receptor. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Specifications
Targets
DR5 & FAP
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
DR5
Host Animal 1
Mouse
Target 2
FAP
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
DR5
Gene ID
UniProt ID
Alternative Names
DR5; Death Receptor 5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; TNFRSF10B
Target 2
FAP
Gene ID
UniProt ID
Alternative Names
FAP; fibroblast activation protein, alpha; FAPA; SIMP; Fibroblast activation protein; DPPIV; prolyl endopeptidase FAP; seprase; FAPalpha; dipeptidyl peptidase FAP; surface-expressed protease; post-proline cleaving enzyme; gelatine degradation protease FAP; F19 cell surface antigen; integral membrane serine protease; serine integral membrane protease; 170 kDa melanoma membrane-bound gelatinase
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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