Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) (BSFAB-152)

Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) is designed to be expressed as three chains derived from the variable domains of anti-DR5 and anti-FAP parental antibodies. It contains a His-tag for affinity purification. And the two Fd regions are connected by a flexible linker. This BsAb can induce targeted apoptosis by activation of the death receptor. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Datasheet

Specifications

Targets

DR5 & FAP

Type

Tandem Fab

Species Reactivity

Human

Target 1

DR5

Host Animal 1

Mouse

Target 2

FAP

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Ovary cancer; Colon cancer; Lung cancer

Targets

Target 1

DR5

Gene ID

8795

UniProt ID

O14763

Alternative Names

DR5; Death Receptor 5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; TNFRSF10B

Target 2

FAP

Gene ID

2191

UniProt ID

B4DLR2

Alternative Names

FAP; fibroblast activation protein, alpha; FAPA; SIMP; Fibroblast activation protein; DPPIV; prolyl endopeptidase FAP; seprase; FAPalpha; dipeptidyl peptidase FAP; surface-expressed protease; post-proline cleaving enzyme; gelatine degradation protease FAP; F19 cell surface antigen; integral membrane serine protease; serine integral membrane protease; 170 kDa melanoma membrane-bound gelatinase

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