Home > Products > EGFR & HER3 > Recombinant Human Anti-EGFR x Human Anti-HER3 Bispecific Antibody (Diabody-Fc)

Recombinant Human Anti-EGFR x Human Anti-HER3 Bispecific Antibody (Diabody-Fc)  (BSDBF-H323)

Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-EGFR and anti-HER3 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Solid tumors therapy.

Specifications
Targets
EGFR & HER3
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Human
Target 2
HER3
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Solid tumors
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
HER3
Gene ID
UniProt ID
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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